Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvage.
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ABSTRACT:
SUBMITTER: Krishnan A
PROVIDER: S-EPMC6970920 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Vitamin and cofactor acquisition in apicomplexans: Synthesis <i>versus</i> salvage.
Krishnan Aarti A Kloehn Joachim J Lunghi Matteo M Soldati-Favre Dominique D
The Journal of biological chemistry 20191125 3
The Apicomplexa phylum comprises diverse parasitic organisms that have evolved from a free-living ancestor. These obligate intracellular parasites exhibit versatile metabolic capabilities reflecting their capacity to survive and grow in different hosts and varying niches. Determined by nutrient availability, they either use their biosynthesis machineries or largely depend on their host for metabolite acquisition. Because vitamins cannot be synthesized by the mammalian host, the enzymes required ...[more]
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