Revealing factors determining immunodominant responses against dominant epitopes.

ABSTRACT: Upon recognition of peptide-MHC complexes by T cell receptors (TCR), the cognate T cells expand and differentiate into effector T cells to generate protective immunity. Despite the fact that any immune response generates a diverse set of TCR clones against a particular epitope, only a few clones are highly expanded in any immune response. Previous studies observed that the highest frequency clones usually control viral infections better than subdominant clones, but the reasons for this dominance among T cell clones are still unclear. Here, we used publicly available TCR amino acid sequences to study which factors determine whether a response becomes immunodominance (ID) per donor; we classified the largest T cell clone as the epitope-specific dominant clone and all the other clones as subd

SUBMITTER: Ritmahan W 

PROVIDER: S-EPMC6971151 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature