Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy.

ABSTRACT: High-throughput genome sequencing and computation have enabled rapid identification of targets for personalized medicine, including cancer vaccines. Synthetic peptides are an established mode of cancer vaccine delivery, but generating the peptides for each patient in a rapid and affordable fashion remains difficult. High-throughput peptide synthesis technology is therefore urgently needed for patient-specific cancer vaccines to succeed in the clinic. Previously, we developed automated flow peptide synthesis technology that greatly accelerates the production of synthetic peptides. Herein, we show that this technology permits the synthesis of high-quality peptides for personalized medicine. Automated flow synthesis produces 30-mer peptides in less than 35 minutes and 15- to 16-mer peptides i

SUBMITTER: Truex NL 

PROVIDER: S-EPMC6971261 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature