Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.

ABSTRACT: Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative breast cancer patients. However, our knowledge of Nup93 function in breast cancer besides its role as structural component of the nuclear pore complex is not understood. Combination of functional assays and genetic analyses suggested that chromatin interaction of Nup93 partially modulates the expression of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal transition, resulting in impaired invasion of triple-negative, claudin-low breast cancer cells. Nup93 depletion induced stress fiber formation associated with reduced cell migration/proliferation and impaired expression of mesenchymal-like genes. Silencing LIMCH1, a gene responsible for actin cytoskeleton remo

SUBMITTER: Bersini S 

PROVIDER: S-EPMC6971368 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature