Can the global end-diastolic volume index guide fluid management in septic patients? A multicenter randomized controlled trial.

ABSTRACT:

Aim

An index that accurately measures intravascular volume is paramount for the optimal resuscitation of sepsis. Selecting an adequate indicator to substitute for central venous pressure (CVP) has remained an issue. The objective of our study was to compare the usefulness of standard early goal-directed therapy (EGDT) with CVP (EGDT-CVP) and modified EGDT with global end-diastolic volume index (GEDI; EGDT-GEDI) for sepsis.

Methods

This was a multicenter prospective randomized controlled study. All patients with sepsis who were expected to require mechanical ventilator support for a minimum of 48 h were included. The patients were classified into an EGDT-CVP group and an EGDT-GEDI group. All participants underwent the extubation protocol. The primary outcome was the ventilato

SUBMITTER: Morisawa K 

PROVIDER: S-EPMC6971429 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature