Injectable supramolecular polymer-nanoparticle hydrogels enhance human mesenchymal stem cell delivery.

ABSTRACT: Stem cell therapies have emerged as promising treatments for injuries and diseases in regenerative medicine. Yet, delivering stem cells therapeutically can be complicated by invasive administration techniques, heterogeneity in the injection media, and/or poor cell retention at the injection site. Despite these issues, traditional administration protocols using bolus injections in a saline solution or surgical implants of cell-laden hydrogels have highlighted the promise of cell administration as a treatment strategy. To address these limitations, we have designed an injectable polymer-nanoparticle (PNP) hydrogel platform exploiting multivalent, noncovalent interactions between modified biopolymers and biodegradable nanoparticles for encapsulation and delivery of human mesenchymal stem cell

SUBMITTER: Grosskopf AK 

PROVIDER: S-EPMC6971438 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature