Sprayable and biodegradable, intrinsically adhesive wound dressing with antimicrobial properties.

ABSTRACT: Conventional wound dressings are difficult to apply to large total body surface area (TBSA) wounds, as they typically are prefabricated, require a layer of adhesive coating for fixation, and need frequent replacement for entrapped exudate. Large TBSA wounds as well as orthopedic trauma and low-resource surgery also have a high risk of infection. In this report, a sprayable and intrinsically adhesive wound dressing loaded with antimicrobial silver is investigated that provides personalized fabrication with minimal patient contact. The dressing is composed of adhesive and biodegradable poly(lactic-co-glycolic acid) and poly(ethylene glycol) (PLGA/PEG) blend fibers with or without silver salt (AgNO₃). in vitro studies demonstrate that the PLGA/PEG/Ag dressing has antimicrobi

SUBMITTER: Daristotle JL 

PROVIDER: S-EPMC6971445 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature