Immunomodulation Followed by Antigen-Specific T_reg Infusion Controls Islet Autoimmunity.

ABSTRACT: Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4⁺Foxp3⁺ regulatory T cells (T_regs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded T_regs in T1D and solid-organ transplant recipients are limited by poor T_reg engraftment without host manipulation. We showed that T_reg engraftment and therapeutic benefit in nonautoimmune models required ablative host conditioning. Here, we evaluated T_reg engraftment and therapeutic efficacy in the nonobese diabetic (NOD) mouse model of autoimmune diabetes using nonablative, combinatorial regimens involving the anti-CD3 (αCD3), cycloph

SUBMITTER: Cabello-Kindelan C 

PROVIDER: S-EPMC6971488 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature