Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial.

ABSTRACT:

Background

Mild cognitive impairment (MCI) is a global-scale issue, due in large part to the rapidly growing elderly population. The main polyphenol contained in coffee beans, chlorogenic acid (CGA), improves attention in healthy individuals. The utility of CGAs for treating MCI, however, has not been evaluated.

Objective

To determine the effects of continuous CGA intake on cognitive function, especially attention, in patients diagnosed with MCI.

Methods

The study was a randomized controlled crossover trial including 34 patients with MCI. Participants were randomly divided into two groups: Those who first ingested a placebo beverage and those who first ingested an active beverage containing CGAs (553.6 mg/bottle) twice daily for 12 weeks. After a 4-week washout period

SUBMITTER: Ochiai R 

PROVIDER: S-EPMC6971825 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature