Molecular alterations of the TLR4-signaling cascade in canine epilepsy.

ABSTRACT: BACKGROUND:Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor. However, there is an apparent lack of information about expression alterations affecting this pathway in canine patients with epilepsy. Therefore, we have analyzed the expression pattern of Toll-like receptor 4 and its ligands in brain tissue of canine patients with structural or idiopathic epilepsy in comparison with tissue from laboratory dogs or from owner-kept dogs without neurological diseases. RESULTS:The analysis revealed an overexpression of Toll-like receptor-4 in the CA3 region of dogs with structural epilepsy. Further analysis provided evidence for an upregulation of Toll-like receptor

SUBMITTER: von Ruden EL 

PROVIDER: S-EPMC6971886 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature