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Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study.

ABSTRACT: BACKGROUND:We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage HIV drug resistance. A retrospective cohort study utilizing clinical data and stored samples. Patients received ART at three Nigerian treatment centres. Plasma samples stored when they were in VF were genotyped. RESULT:Of 126 patients with samples available, 57 were successfully genotyped. From ART initiation, the proportion of patients with adherence ≥90% increased steadily from 54% at first high viral load (VL) to 67% at confirmed VF, and 81% at time of re-suppressed VL. Sixteen (28%) patients had at least one DRM. Forty-six (81%) patients had full susceptibility to the three drugs in their first-line (1 L) regimen. Thirteen (23%) were resistant to at least one antiretroviral drug but three were resistant to drugs not used in Nigeria. Ten patients had resistance to their 1 L drug(s) and six were fully susceptible to the three drugs in the recommended second-line regimen. CONCLUSION:This cohort had little drug resistance mutations. We conclude that if adherence is not assured, patients could exhibit virologic failure without having developed mutations associated with drug resistance.

SUBMITTER: Onwuamah CK

PROVIDER: S-EPMC6971913 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study.

Onwuamah Chika K CK Okpokwu Jonathan J Audu Rosemary R Imade Godwin G Meloni Seema T ST Okwuraiwe Azuka A Chebu Philippe P Musa Adesola Z AZ Chaplin Beth B Dalhatu Ibrahim I Agbaji Oche O Samuels Jay J Ezechi Oliver O Ahmed Mukhtar M Odaibo Georgina G Olaleye David O DO Okonkwo Prosper P Salako Babatunde Lawal BL Raizes Elliot E Yang Chunfu C Kanki Phyllis J PJ Idigbe Emmanuel O EO

BMC microbiology 20200120 1

<h4>Background</h4>We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage HIV drug resistance. A retrospective cohort study utilizing clinical data and stored samples. Patients received ART at three Nigerian treatment centres. Plasma samples stored when they were in VF were genotyped.<h4>Result</h4>Of 126 patients with samples available, 57 wer ...[more]

PMID: 31959116

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Dataset Information

Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study.

Publications

Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study.

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