Feasibility of closed-loop titration of norepinephrine infusion in patients undergoing moderate- and high-risk surgery.

ABSTRACT: BACKGROUND:Vasopressor agents are used to prevent intraoperative hypotension and ensure adequate perfusion. Vasopressors are usually administered as intermittent boluses or manually adjusted infusions, but this practice requires considerable time and attention. We have developed a closed-loop vasopressor (CLV) controller to correct hypotension more efficiently. Here, we conducted a proof-of-concept study to assess the feasibility and performance of CLV control in surgical patients. METHODS:Twenty patients scheduled for elective surgical procedures were included in this study. The goal of the CLV system was to maintain MAP within 5 mm Hg of the target MAP by automatically adjusting the rate of a norepinephrine infusion using MAP values recorded continuously from an arterial catheter. The pr

SUBMITTER: Joosten A 

PROVIDER: S-EPMC6972231 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature