Effect of multidose drug dispensing on the time in therapeutic range in patients using vitamin-K antagonists: A randomized controlled trial.

ABSTRACT:

Background

A high number of vitamin K antagonist (VKA) users have a low proportion of time in therapeutic range (TTR) resulting in a high number of bleeding and thromboembolism events.

Objective

Can the quality of anticoagulation be improved by dispensing VKAs via multidose drug dispensing (MDD).

Method

A randomized controlled trial in the Netherlands. Patients who used VKAs, ≥65 years of age with a TTR <65% were eligible for inclusion. All oral drugs were dispensed via MDD. In MDD systems, all oral chronic medication intended for one dosing moment is packed in plastic disposable pouches. Controls received VKAs by manual dispensing. The difference in TTR between the 6 months after- and 6 months before the index date. A mixed-effects model with the intervention, TTR be

SUBMITTER: Mertens BJ 

PROVIDER: S-EPMC6972487 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature