Genomics of periodontal disease and tooth morbidity.

ABSTRACT: In this review we critically summarize the evidence base and the progress to date regarding the genomic basis of periodontal disease and tooth morbidity (ie, dental caries and tooth loss), and discuss future applications and research directions in the context of precision oral health and care. Evidence for these oral/dental traits from genome-wide association studies first emerged less than a decade ago. Basic and translational research activities in this domain are now under way by multiple groups around the world. Key departure points in the oral health genomics discourse are: (a) some heritable variation exists for periodontal and dental diseases; (b) the environmental component (eg, social determinants of health and behavioral risk factors) has a major influence on the population distr

SUBMITTER: Morelli T 

PROVIDER: S-EPMC6972532 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature