A Photoactivatable Small-Molecule Probe for the In Vivo Capture of Polyketide Intermediates.

ABSTRACT: A photolabile carba(dethia) malonyl N-acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium Streptomyces lasaliensis, a previously undetected cyclised intermediate was identified and characterised, providing a new outlook on the timing of substrate processing.

SUBMITTER: Kilgour SL 

PROVIDER: S-EPMC6972646 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature