The association between vaginal bacterial composition and miscarriage: a nested case-control study.

ABSTRACT:

Objective

To characterise vaginal bacterial composition in early pregnancy and investigate its relationship with first and second trimester miscarriages.

Design

Nested case-control study.

Setting

Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London.

Population

161 pregnancies: 64 resulting in first trimester miscarriage, 14 in second trimester miscarriage and 83 term pregnancies.

Methods

Prospective profiling and comparison of vaginal bacteria composition using 16S rRNA gene-based metataxonomics from 5 weeks' gestation in pregnancies ending in miscarriage or uncomplicated term deliveries matched for age, gestation and body mass index.

Main outcome measures

Relative vaginal bacteria abundance, diversity and richness

SUBMITTER: Al-Memar M 

PROVIDER: S-EPMC6972675 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature