Bayesian model selection for the study of Hardy-Weinberg proportions and homogeneity of gender allele frequencies.

ABSTRACT: Standard statistical tests for Hardy-Weinberg equilibrium assume the equality of allele frequencies in the sexes, whereas tests for the equality of allele frequencies in the sexes assume Hardy-Weinberg equilibrium. This produces a circularity in the testing of genetic variants, which has recently been resolved with new frequentist likelihood and exact procedures. In this paper, we tackle the same problem by posing it as a Bayesian model comparison problem. We formulate an exhaustive set of ten alternative scenarios for biallelic genetic variants. Using Dirichlet and Beta priors for genotype and allele frequencies, we derive marginal likelihoods for all scenarios, and select the most likely scenario using the posterior probabilities that each of these scenarios is the one in place. Differen

SUBMITTER: Puig X 

PROVIDER: S-EPMC6972714 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature