Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.

ABSTRACT: The liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent years, attention has been directed towards the liver sinusoidal endothelial cells (LSECs), which play a central role in liver innate immunity by their ability to scavenge pathogen- and damage-associated molecular patterns. Every day our bodies are exposed to billions of gut-derived pathogens which must be efficiently removed from the circulation to prevent inflammatory and/or immune reactions in other vascular beds. Here, we have used GFP-labelled Enterobacteria phage T4 (GFP-T4-

SUBMITTER: Oie CI 

PROVIDER: S-EPMC6972739 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature