Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window.

ABSTRACT: During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC). Perturbations in this process, termed decidualization, leads to breakdown of the feto-maternal interface and miscarriage, but the underlying mechanisms are poorly understood. Here, we reconstructed the decidual pathway at single-cell level in vitro and demonstrate that stromal cells first mount an acute stress response before emerging as DC or senescent DC (snDC). In the absence of immune cell-mediated clearance of snDC, secondary senescence transforms DC into progesterone-resistant cells that abundantly express extracellular matrix remodelling factors. Additional single-cell analysis of midluteal endometrium identi

SUBMITTER: Lucas ES 

PROVIDER: S-EPMC6972755 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature