N-Heterocyclic Carbene Acyl Anion Organocatalysis by Ball-Milling.

ABSTRACT: The ability to conduct N-heterocyclic carbene-catalysed acyl anion chemistry under ball-milling conditions is reported for the first time. This process has been exemplified through applications to intermolecular-benzoin, intramolecular-benzoin, intermolecular-Stetter and intramolecular-Stetter reactions including asymmetric examples and demonstrates that this mode of mechanistically complex organocatalytic reaction can operate under solvent-minimised conditions.

SUBMITTER: Nicholson WI 

PROVIDER: S-EPMC6972762 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature