Profiling of human lymphocytes reveals a specific network of protein kinases modulated by endurance training status.

ABSTRACT: To date, the effects of endurance exercise training on lymphocyte physiology at the kinome level are largely unknown. Therefore, the present study used a highly sensitive peptide-based kinase activity profiling approach to investigate if the basal activity of tyrosine (Tyr) and serine/threonine (Ser/Thr) kinases of human lymphocytes is affected by the aerobic endurance training status. Results revealed that the activity of various tyrosine kinases of the FGFR family and ZAP70 was increased, whereas the activity of multiple Ser/Thr kinases such as IKK_α, CaMK4, PKA_α, PKC_α+δ (among others) was decreased in lymphocytes of endurance trained athletes (ET). Moreover, functional associations between several differentially regulated kinases in ET-derived lymphocytes

SUBMITTER: Alack K 

PROVIDER: S-EPMC6972788 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature