Understanding the Localization of Berylliosis: Interaction of Be²⁺ with Carbohydrates and Related Biomimetic Ligands.

ABSTRACT: The interplay of metal ions with polysaccharides is important for the immune recognition in the lung. Due to the localization of beryllium associated diseases to the lung, it is likely that beryllium carbohydrate complexes play a vital role for the development of berylliosis. Herein, we present a detailed study on the interaction of Be²⁺ ions with fructose and glucose as well as simpler biomimetic ligands, which emulate binding motives of saccharides. Through NMR and IR spectroscopy as well as single-crystal X-ray diffraction, complemented by competition reactions we were able to determine a distinctive trend in the binding affinity of these ligands. This suggests that under physiological conditions beryllium ions are only bound irreversibly in glycoproteins or polysaccharides i

SUBMITTER: Muller M 

PROVIDER: S-EPMC6973027 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature