Effects of Vitamin D₂ (Ergocalciferol) and D₃ (Cholecalciferol) on Atlantic Salmon (Salmo salar) Primary Macrophage Immune Response to Aeromonas salmonicida subsp. salmonicida Infection.

ABSTRACT: Vitamin D₂ (ergocalciferol) and vitamin D₃ (cholecalciferol) are fat-soluble secosteroid hormones obtained from plant and animal sources, respectively. Fish incorporates vitamin D₂ and D₃ through the diet. In mammals, vitamin D forms are involved in mineral metabolism, cell growth, tissue differentiation, and antibacterial immune response. Vitamin D is an essential nutrient in aquafeeds for finfish. However, the influence of vitamin D on fish cell immunity has not yet been explored. Here, we examined the effects of vitamin D₂ and vitamin D₃ on Salmo salar primary macrophage immune response to A. salmonicida subspecies salmonicida infection under in vitro conditions. We determined that high concent

SUBMITTER: Soto-Davila M 

PROVIDER: S-EPMC6973134 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature