Polygenic risk scores in schizophrenia with clinically significant copy number variants.

ABSTRACT:

Aims

Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared.

Methods

The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and without 'clinically significant' CNV.

Results

First, we replicated the higher PRS in patients with SCZ compared to that in HC (without taking into account the CNV). For clinically

SUBMITTER: Taniguchi S 

PROVIDER: S-EPMC6973280 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature