A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types.

ABSTRACT: RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive expression landscape of 1504 RBPs across 16 human cancer types, which revealed that RBPs are predominantly upregulated in tumours and this phenomenon is affected by the tumour immune subtypes and microenvironment. Across different cancer types, 109 RBPs are consistently upregulated while 41 RBPs are consistently downregulated. These up-regulated and down-regulated RBPs show distinct molecular characteristics and prognostic effects, whereas their dysregulation is mediated by di

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6973330 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature