The P2X₇ receptor tracer [¹¹C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study.

ABSTRACT:

Purpose

The novel PET tracer [¹¹C]SMW139 binds with high affinity to the P2X₇ receptor, which is expressed on pro-inflammatory microglia. The purposes of this first in-man study were to characterise pharmacokinetics of [¹¹C]SMW139 in patients with active relapsing remitting multiple sclerosis (RRMS) and healthy controls (HC) and to evaluate its potential to identify in vivo neuroinflammation in RRMS.

Methods

Five RRMS patients and 5 age-matched HC underwent 90-min dynamic [¹¹C]SMW139 PET scans, with online continuous and manual arterial sampling to generate a metabolite-corrected arterial plasma input function. Tissue time activity curves were fitted to single- and two-tissue compartment models, and the model that provided the best

SUBMITTER: Hagens MHJ 

PROVIDER: S-EPMC6974509 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature