Moraxella catarrhalis Promotes Stable Polymicrobial Biofilms With the Major Otopathogens.

ABSTRACT: Otitis media (OM) is a prevalent pediatric infection characterized by painful inflammation of the middle ear. The Gram-negative diplococcus Moraxella catarrhalis is a commensal of the nasopharynx and one of three leading causative agents of OM. The most recent work on this multifaceted disease indicates that biofilms and polymicrobial infections play a pivotal role in recurrent and chronic OM, which are difficult to eradicate using standard antibiotic protocols. Although there have been significant advances in OM research, the actual bacterial and viral interactions leading to pathogenesis remain largely uncharacterized. However, colonization and persistence in the nasopharynx is clearly an essential first step. In this study, we assessed the role M. catarrhalis plays in the co-colonizatio

SUBMITTER: Bair KL 

PROVIDER: S-EPMC6974515 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature