Aging Disrupts the Circadian Patterns of Protein Expression in the Murine Hippocampus.

ABSTRACT: Aging is associated with cognitive decline and dysregulation of the circadian system, which modulates hippocampal-dependent memory as well as biological processes underlying hippocampal function. While circadian dysfunction and memory impairment are common features of aging and several neurodegenerative brain disorders, how aging impacts the circadian expression patterns of proteins involved in processes that underlie hippocampal-dependent memory is not well understood. In this study, we profiled the hippocampal proteomes of young and middle-aged mice across two circadian cycles using quantitative mass spectrometry in order to explore aging-associated changes in the temporal orchestration of biological pathways. Of the ∼1,420 proteins that were accurately quantified, 15% (214 proteins) dis

SUBMITTER: Adler P 

PROVIDER: S-EPMC6974521 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature