How Bacterial Chemoreceptors Evolve Novel Ligand Specificities.

ABSTRACT: Chemoreceptor-based signaling pathways are among the major modes of bacterial signal transduction, and Pseudomonas aeruginosa PAO1 is an important model to study their function. Of the 26 chemoreceptors of this strain, PctA has a broad ligand range and responds to most of the proteinogenic amino acids, whereas PctB and PctC have a much narrower range and show strong ligand preference for l-glutamine and γ-aminobutyrate, respectively. Using several comparative genomics approaches, we show that these receptors are paralogs: pctA gene duplication in the common ancestor of the genus Pseudomonas led to pctC, whereas pctB originated through another, independent pctA duplication in the common ancestor of P. aeruginosa Thus, the broad-range amino ac

SUBMITTER: Gavira JA 

PROVIDER: S-EPMC6974571 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature