Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses.

ABSTRACT: Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related to CVD has developed, with an emphasis on identifying strategies for the prevention and effective treatment of CVD. In this review, we critically examine the existing CVD literature, and specifically highlight the contribution of Mendelian randomization analyses in CVD research. Throughout this review, we assess the extent to which research findings agree across a range of studies of differing design within a triangulation framework. If differing study designs are subject to non-overlapping sources of bias, consistent findings limit the extent to which results are merely an art

SUBMITTER: Spiller W 

PROVIDER: S-EPMC6974657 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature