Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.

ABSTRACT: Although aging and senescence have been extensively studied in the past few decades, however, there is lack of clinical treatment available for anti-aging. This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts (2BS and WI38). BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically, BBR imp

SUBMITTER: Dang Y 

PROVIDER: S-EPMC6974710 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature