Cell senescence contributes to tissue regeneration in zebrafish.

ABSTRACT: Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance of these cells can lead to their accumulation during aging with deleterious effects. Despite this potential negative side of cell senescence, its physiological role as a pro-regenerative and morphogenetic force has emerged recently after the identification of programmed cell senescence during embryogenesis and during wound healing and limb regeneration. Here, we explored the conservation of tissue injury-induced senescence in a model of complex regeneration, the zebrafish. Fin amputation in adult fish led to the appearance of senescent cells at the site of damage, and th

SUBMITTER: Da Silva-Alvarez S 

PROVIDER: S-EPMC6974711 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature