Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging.

ABSTRACT: Aging is characterized by the deterioration of tissue structure and function. In skin, environmental factors, for example, ultraviolet radiation (UVR), can accelerate the effects of aging such as decline in barrier function and subsequent loss of hydration. Water homeostasis is vital for all cellular functions and it is known that organic osmolyte transport is critical to this process. Therefore, we hypothesized that as we age, these tightly controlled physiological mechanisms become disrupted, possibly due to loss of transporter expression. We investigated this in vivo, using human skin samples from photoprotected and photoexposed sites of young and aged volunteers. We show a reduction in keratinocyte cell size with age and a downregulation of osmolyte transporters SMIT and TAUT with both

SUBMITTER: Foster AR 

PROVIDER: S-EPMC6974728 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature