Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d^-/- Mice Lacking NKT Cells.

ABSTRACT: Although the Japanese traditional herbal medicine (Kampo), Juzentaihoto (JTT), has been reported to have antitumor effects in several tumor models, its role in tumor immunology remains controversial. In the present study, we tested whether oral administration of JTT enhances antitumor immunity in CD1d^-/- mice, in which immunosuppression was partially relieved due to the lack of NKT cells. In a subcutaneous murine syngeneic CT26 colorectal tumor model, JTT had no impact on tumor growth in wild type (WT) BALB/c mice. However, the growth rate of tumors was significantly slower in CD1d^-/- mice than in WT mice. Surprisingly, JTT significantly delayed tumor growth in such CD1d^-/- mice. In vivo depletion of CD8⁺ T cells revealed that CD8⁺ T c

SUBMITTER: Takaku S 

PROVIDER: S-EPMC6974754 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature