Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility.

ABSTRACT: Endometriosis an important cause of female infertility and seriously impact physical and psychological health of patients. Endometriosis is now considered to be a public health problem that deserves in-depth investigation, especially the etiopathogenesis of endometriosis-associated infertility. We aimed to illuminate the etiopathogenesis of endometriosis-associated infertility that involve excessive oxidative stress (OS) induced pathological changes of ovary cumulus granulosa cell (GCs). Senescence-associated β-galactosidase (SA β-gal) activity in GCs from endometriosis patients, soluble isoform of advanced glycation end products receptor (sRAGE) expression in follicular fluid from endometriosis patients and differentially expressed senescence-associated secretory phenotype factors (IL-1β,

SUBMITTER: Lin X 

PROVIDER: S-EPMC6974790 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature