A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy.

ABSTRACT: BACKGROUND AND PURPOSE:Square-wave jerks (SWJs) are the most common saccadic intrusion in progressive supranuclear palsy (PSP), but their genesis is uncertain. We aimed to determine the characteristics of SWJs in PSP (the Richardson subtype) and Parkinson's disease (PD) and to map the brain structures responsible for abnormal SWJ parameters in PSP. METHODS:Eye movements in 12 patients with PSP, 12 patients with PD, and 12 age-matched healthy controls were recorded using an infrared corneal reflection device. The rate, mean amplitude, and velocity of SWJs were analyzed offline. Voxel-based morphometry using a 3-Tesla MRI scanner was performed to relate changes in brain volume to SWJ parameters. RESULTS:The SWJ rate was more than threefold higher in PSP patients than in both PD patients and

SUBMITTER: Anagnostou E 

PROVIDER: S-EPMC6974821 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature