The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis.

ABSTRACT: Psychotic disorders are characterized by theory of mind (ToM) impairment. Although ToM undergoes maturational changes throughout adolescence, there is a lack of studies examining ToM performance and its brain functional correlates in individuals with an early onset of psychosis (EOP; onset prior to age 18), and its relationship with age. Twenty-seven individuals with EOP were compared with 41 healthy volunteers using the "Reading-the-Mind-in-the-Eyes" Test, as a measure of ToM performance. A resting-state functional MRI scan was also acquired, in which the default mode network was used to identify areas relevant to ToM processing employing independent component analysis. Group effects revealed worse ToM performance and less intrinsic functional connectivity in the medial prefrontal cortex

SUBMITTER: Ilzarbe D 

PROVIDER: S-EPMC6974903 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature