Ontology highlight
ABSTRACT:
SUBMITTER: He RY
PROVIDER: S-EPMC6974936 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
He Ruei-Yu RY Lai Xiang-Me XM Sun Chia-Sui CS Kung Te-Shien TS Hong Jhu-Ying JY Jheng Yu-Song YS Liao Wei-Neng WN Chen Jen-Kun JK Liao Yung-Feng YF Tu Pang-Hsien PH Huang Joseph Jen-Tse JJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20191209 2
Finding an effective therapeutic regimen is an urgent demand for various neurodegenerative disorders including Huntington's disease (HD). For the difficulties in observing the dynamic aggregation and oligomerization process of mutant Huntingtin (mHtt) in vivo, the evaluation of potential drugs at the molecular protein level is usually restricted. By combing lifetime-based fluorescence microscopies and biophysical tools, it is showcased that a designed amphiphilic peptide, which targets the mHtt ...[more]