Dataset Information

2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.

ABSTRACT: The residual of malignant tumor cells and lack of bone-tissue integration are the two critical concerns of bone-tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti3C2 MXene is reported with 3D-printing bioactive glass (BG) scaffolds for achieving concurrent bone-tumor killing by photonic hyperthermia and bone-tissue regeneration by bioactive scaffolds. The designed composite scaffolds take the unique feature of high photothermal conversion of integrated 2D Ti3C2 MXene for inducing bone-tumor ablation by near infrared-triggered photothermal hyperthermia, which has achieved the complete tumor eradication on in vivo bone-tumor xenografts. Importantly, the rational integration of 2D Ti3C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds. The dual functionality of bone-tumor killing and bone-tissue regeneration makes these Ti3C2 MXene-integrated composite scaffolds highly promising for the treatment of bone tumors, which also substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone tumors.

SUBMITTER: Pan S

PROVIDER: S-EPMC6974945 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.

Pan Shanshan S Yin Junhui J Yu Luodan L Zhang Changqing C Zhu Yufang Y Gao Youshui Y Chen Yu Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20191126 2

The residual of malignant tumor cells and lack of bone-tissue integration are the two critical concerns of bone-tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti<sub>3</sub>C<sub>2</sub> MXene is reported with 3D-printing bioactive glass (BG) scaffolds for achieving concurrent bone-tumor killing by photonic hyperthermia and bone-tissue regeneration by bioactive scaffolds. The designed composite scaffolds take the unique feature of high photothermal conversion ...[more]

PMID: 31993282

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Project description:BackgroundCraniosynostosis is a congenital condition characterized by the premature fusion of cranial sutures, leading to potential complications such as abnormal skull growth, increased intracranial pressure, and cognitive delays. Traditionally, open cranial vault reconstruction (OCVR) has been used to treat this condition. However, it is highly subjective and greatly dependent on the surgeon's expertise, which can lead to residual deformities and the need for reoperation. Effective preoperative planning can greatly improve surgical outcomes, although the major challenge is accurately translating this plan into the clinical setting. Recently, augmented reality (AR) and 3D printing have emerged as promising technologies to facilitate this endeavor. In this work, we propose three alternatives, leveraging these technologies, to guide the precise repositioning of remodeled bone fragments in the patient.MethodsThe three guidance methods are AR on a tablet, AR with Microsoft HoloLens 2, and 3D-printed spacers. The accuracy of each method was assessed by measuring the deviation of each bone fragment from the virtual surgical plan (VSP) in a simulated environment using 3D-printed phantoms based on a 14-month-old boy with trigonocephaly. The same assessment was also performed during his actual surgery.ResultsAll three guidance methods demonstrated similar levels of accuracy, with mean placement errors below 1 mm in all cases. The AR systems allowed for real-time adjustments, enhancing precision. Statistical analysis showed no significant differences in error rates between the different methods or attempts.ConclusionsIntegrating AR and 3D printing into craniosynostosis surgery holds great potential for improving OCVR. While 3D-printed spacers are useful when digital technologies are unavailable, AR-based methods provide more comprehensive guidance. Nevertheless, our study suggests that the choice may depend more on the specific clinical context, user-specific skills, and available resources rather than on a clear superiority of one method over the others.

Dataset Information

2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.

Publications

2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.

Similar Datasets

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