Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth factors, chemokines, cytokines and extracellular vesicles-collectively termed the secretome. In this study, we assessed for the first time the efficacy of the IL-1α-primed MSC-derived secretome on brain injury and functional recovery after cerebral ischaemia.

Methods

Stroke was induced in male C57BL/6 mice using the intraluminal filament model of middle cerebral artery occlusion. Conditioned medium from IL-1α-primed MSCs or vehicle was administered at the time of reperfusion or at 24 h post-stroke by subcutaneous injection.

Results

IL-1α-primed MSC-deriv

SUBMITTER: Cunningham CJ 

PROVIDER: S-EPMC6975095 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature