Prominent immune signatures of T cells are specifically associated with indolent B-cell lymphoproliferative disorders and predict prognosis.

ABSTRACT:

Objectives

T cells play an essential role in controlling the development of B-cell lymphoproliferative disorders (BLPDs), but the dysfunction of T cells in BLPDs largely remains elusive.

Methods

Using multiplexed flow cytometry, we quantified all major subsets of CD4⁺ helper T cells (Th) and CD8⁺ cytotoxic T cells (Tc) in 94 BLPD patients and 66 healthy controls. Statistics was utilised to rank T-cell signatures that distinguished BLPDs from healthy controls and differentially presented between indolent and aggressive categories.

Results

By comparing with healthy controls, we found that the indolent but not aggressive type of BLPDs demonstrated a high degree of T-cell activation, showing the increase in type I helper T (Th1) cells and follicular

SUBMITTER: Yi S 

PROVIDER: S-EPMC6975127 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature