Effects of neural stem cell transplantation on the motor function of rats with contusion spinal cord injuries: a meta-analysis.

ABSTRACT:

Objective

To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs).

Data sources

Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase and Cochrane databases, and the extracted data were analyzed by Stata 14.0.

Data selection

Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the Basso, Beattie, and Bresnahan lo-comotor rating scale. Exclusion criteria included a follow-up of less than 4 weeks and the lack of control groups.

Outcome measures

The restoration

SUBMITTER: Qian K 

PROVIDER: S-EPMC6975148 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature