Optical catapulting of microspheres in mucus models-toward overcoming the mucus biobarrier.

ABSTRACT: The generalized phase contrast method is employed as an efficient "phase-only" laser beam-shaping technique in an optical setup built for catapulting microspheres through simple mucus models. The influence of the laser power and mucin concentration on the motion of the microspheres is investigated in terms of instant and average velocities on a 250-μm trajectory, corresponding to the mucus thickness in the human gastrointestinal tract. Increasing the laser power leads to higher velocities in all the tested samples, while increasing the mucin concentration leads to significant velocity decrease for similar laser input power. However, velocities of up to 95  μm  ·  s  -  1 are demonstrated in a 5% mucin simple mucus model using our catapulting system. This study contributes to understanding

SUBMITTER: Bunea AI 

PROVIDER: S-EPMC6975190 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature