Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation.

ABSTRACT: Differently from other myeloid cells, microglia derive exclusively from precursors originating within the yolk sac and migrate to the CNS under development, without any contribution from fetal liver or postnatal hematopoiesis. Consistent with their unique ontology, microglia may express specific physiological markers, which have been partly described in recent years. Here we wondered whether profiles distinguishing microglia from peripheral macrophages vary with age and under pathology. To this goal, we profiled transcriptomes of microglia throughout the lifespan and included a parallel comparison with peripheral macrophages under physiological and neuroinflammatory settings using age- and sex-matched wild-type and bone marrow chimera mouse models. This comprehensive approach demonstrated

SUBMITTER: Grassivaro F 

PROVIDER: S-EPMC6975289 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature