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Innovations in population intervention research capacity: the contributions of Canada on the Move.

ABSTRACT: The Canada on the Move project developed within a dynamic context and in response to an expressed need for increased capacity to support research involving population-level interventions. This article describes a) the movement to create an organized approach to chronic disease prevention in Canada, b) the emerging science of population-level intervention, c) the development of Canadian infrastructure to support population intervention science, and d) the contribution of Canada on the Move in developing a health research platform and, opportunistically, instigating a study which included assessment of the population impact of a commercial marketing initiative.

SUBMITTER: Cameron R

PROVIDER: S-EPMC6975831 | biostudies-literature | 2006 Mar-Apr

REPOSITORIES: biostudies-literature

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Innovations in population intervention research capacity: the contributions of Canada on the Move.

Cameron Roy R Bauman Adrian A Rose Adria A

Canadian journal of public health = Revue canadienne de sante publique 20060301

The Canada on the Move project developed within a dynamic context and in response to an expressed need for increased capacity to support research involving population-level interventions. This article describes a) the movement to create an organized approach to chronic disease prevention in Canada, b) the emerging science of population-level intervention, c) the development of Canadian infrastructure to support population intervention science, and d) the contribution of Canada on the Move in dev ...[more]

PMID: 16676832

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Project description:ObjectiveTo describe the contributions of prescribed and non-prescribed opioids to opioid related deaths.DesignPopulation based cohort study.SettingOntario, Canada, from 1 January 2013 to 31 December 2016.ParticipantsAll Ontarians who died of an opioid related cause.ExposureActive opioid prescriptions, defined as those with a duration overlapping the date of death, and recent opioid prescriptions, defined as those dispensed in the 30 and 180 days preceding death. Postmortem toxicology results from the Drug and Drug/Alcohol Related Death database were used to characterise deaths on the basis of presence of prescribed and non-prescribed (that is, diverted or illicit) opioids, overall and stratified by year and age.Results2833 opioid related deaths occurred. An active opioid prescription on the date of death was relatively common but declined slightly throughout the study period (38.2% (241/631) in 2013 and 32.5% (278/855) in 2016; P for trend=0.03). Older people and women were relatively more likely to have an active opioid prescription at time of death. In 2016, 46% (169/364) of people aged 45-64 had an active opioid prescription compared with only 12% (8/69) among those aged 24 or younger (P for trend<0.001). Similarly, 46% (124/272) of women had an active opioid prescription at time of death compared with 26.4% (154/583) of men (P<0.001). Among people with active opioid prescriptions at time of death, 37.8% (375/993) also had evidence of a non-prescribed opioid on postmortem toxicology. By 2016, the non-prescribed opioid most commonly identified after death was fentanyl (41%; 47 of 115 cases). Among people without an active opioid prescription at time of death, fentanyl was detected in 20% (78/390) of deaths in 2013, increasing to 47.5% (274/577) by 2016 (P<0.001).ConclusionsPrescribed, diverted, and illicit opioids all play an important role in opioid related deaths. Although more than half of all opioid related deaths still involved prescription drugs (either dispensed or diverted) in 2016, the increased rate of deaths involving fentanyl between 2015 and 2016 is concerning and suggests the need for a multifactorial approach to this problem that considers both the prescribed and illicit opioid environments.

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Innovations in population intervention research capacity: the contributions of Canada on the Move.

Publications

Innovations in population intervention research capacity: the contributions of Canada on the Move.

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