Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme.

ABSTRACT: The metabolic serine hydrolase family is, arguably, one of the largest functional enzyme classes in mammals, including humans, comprising 1-2% of the total proteome. This enzyme family uses a conserved nucleophilic serine residue in the active site to perform diverse hydrolytic reactions and consists of proteases, lipases, esterases, amidases, and transacylases, which are prototypical members of this family. In humans, this enzyme family consists of >250, of which approximately 40% members remain unannotated, in terms of both their endogenous substrates and the biological pathways that they regulate. The enzyme ABHD14B, an outlying member of this family, is also known as CCG1/TAF_II250-interacting factor B, as it was found to be associated with transcription initiation factor TFI

SUBMITTER: Rajendran A 

PROVIDER: S-EPMC6976303 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature