Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study.

ABSTRACT: Background and study aims  Electrochemotherapy is an anticancer treatment that uses electric pulses to facilitate uptake of chemotherapeutic drugs in tumor cells and has proven to have a high local cytotoxic effect with minimal adverse events. Electrochemotherapy has mostly been used in treatment of cutaneous metastases but development of a new endoscopic electrode device has made treatment of colorectal tumors possible. This first-in-man multicenter phase I study investigated safety and efficacy of electrochemotherapy using endoscopic electroporation in patients with colorectal tumors. Patients and methods  Seven patients with colorectal tumors who were deemed ineligible for or had declined standard treatment were included. They were treated with bleomycin either intratumorally or intrave

SUBMITTER: Falk Hansen H 

PROVIDER: S-EPMC6976320 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature