Elevated circulating CD14⁺⁺CD16⁺ intermediate monocytes are independently associated with extracardiac complications after cardiac surgery.

ABSTRACT: Elective cardiac surgery has low procedural complications. However, about 40% of patients develop extracardiac complications including delirium and acute kidney injury. We hypothesized that inflammatory processes and immune cell activation might be associated with these complications. We therefore prospectively included 104 patients undergoing cardiac surgery in our study. We assessed peripheral blood leukocyte populations by flow cytometry and circulating cytokines before operation, after surgery and at days one and four post-operatively. Patients undergoing cardiac surgery showed significantly elevated leukocytes and neutrophils after surgery. On the contrary, monocytes decreased after surgery and significantly increased at days 1 and 4, particularly classical (Mon1,CD14++CD16-) and inte

SUBMITTER: Mossanen JC 

PROVIDER: S-EPMC6976615 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature