Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation.

ABSTRACT: Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher gl

SUBMITTER: Dwi Putra SE 

PROVIDER: S-EPMC6976643 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature