Zebrafish Spinal Cord Repair Is Accompanied by Transient Tissue Stiffening.

ABSTRACT: Severe injury to the mammalian spinal cord results in permanent loss of function due to the formation of a glial-fibrotic scar. Both the chemical composition and the mechanical properties of the scar tissue have been implicated to inhibit neuronal regrowth and functional recovery. By contrast, adult zebrafish are able to repair spinal cord tissue and restore motor function after complete spinal cord transection owing to a complex cellular response that includes axon regrowth and is accompanied by neurogenesis. The mechanical mechanisms contributing to successful spinal cord repair in adult zebrafish are, however, currently unknown. Here, we employ atomic force microscopy-enabled nanoindentation to determine the spatial distributions of apparent elastic moduli of living spinal cord tissue s

SUBMITTER: Mollmert S 

PROVIDER: S-EPMC6976874 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature